Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance

Macrophages play a central role in lung physiology and pathology. In this study, we show in mice that alveolar macrophages (AMs), unlike other macrophage types (interstitial, peritoneal, and splenic macrophages), constitutively express programmed death-1 ligand 1 (PD-L1), thereby possessing a superi...

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Published inThe Journal of immunology (1950) Vol. 207; no. 1; pp. 110 - 114
Main Authors Sun, Fan, Li, Liwen, Xiao, Yadong, Gregory, Alyssa D, Shapiro, Steven D, Xiao, Gutian, Qu, Zhaoxia
Format Journal Article
LanguageEnglish
Published United States 01.07.2021
Subjects
Animals
B7-1 Antigen - immunology
B7-H1 Antigen - immunology
Macrophages, Alveolar - immunology
Mice
Mice, Inbred Strains
Mice, Knockout
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Summary:Macrophages play a central role in lung physiology and pathology. In this study, we show in mice that alveolar macrophages (AMs), unlike other macrophage types (interstitial, peritoneal, and splenic macrophages), constitutively express programmed death-1 ligand 1 (PD-L1), thereby possessing a superior phagocytic ability and the capacity to repress CTLs by - and -interacting with CD80 and programmed death-1 (PD-1), respectively. This extraordinary ability of AMs assures optimal protective immunity and tolerance within the lung. These findings uncover a unique characteristic of AMs and an innate immune function of PD-L1 and CD80 and therefore help in the understanding of lung physiology, diseases, and PD-L1/PD-1-based immunotherapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2100046