Mapping of Aldose Reductase Gene Sequences to Human Chromosomes 1, 3, 7, 9, 11, and 13

• Published in: Genomics (San Diego, Calif.) Vol. 17; no. 3; pp. 560 - 565
• Main Authors: Bateman, J.Bronwyn, Kojis, Tracy, Heinzmann, Camilla, Klisak, Ivana, Diep, Anh, Carper, Deborah, Nishimura, Chihiro, Mohandas, T., Sparkes, Robert S.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.09.1993; Elsevier
• Subjects: 550400 - Genetics; Aldehyde Reductase - genetics; ALDEHYDES; Animals; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; CHEMICAL REACTIONS; Chromosome Mapping; CHROMOSOMES; Chromosomes, Human; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 9; Classical genetics, quantitative genetics, hybrids; DNA, Complementary - genetics; ENZYMES; Fundamental and applied biological sciences. Psychology; GENES; GENETIC MAPPING; Genetics of eukaryotes. Biological and molecular evolution; Human; HUMAN CHROMOSOME 1; HUMAN CHROMOSOME 13; HUMAN CHROMOSOME 14; HUMAN CHROMOSOME 18; HUMAN CHROMOSOME 3; HUMAN CHROMOSOME 7; HUMAN CHROMOSOME 9; HUMAN CHROMOSOMES; Humans; Hybrid Cells; In Situ Hybridization; MAPPING; Mice; ORGANIC COMPOUNDS; OXIDOREDUCTASES; PROTEINS; Pseudogenes; REDUCTION; Genetic mapping; Human; Pseudogene; Nucleotide sequence; Enzyme; C11-Chromosome; C7-Chromosome; C9-Chromosome; Aldehyde reductase; Multigene family; Oxidoreductases; A3-Chromosome; A1-Chromosome
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1993.1372

Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somatic cell hybridization. By in situ hybridization analysis, sequences were localized to human chromosomes 1q32-q42, 3p12, 7q31-q35, 9q22, 11p14-p15, and 13q14-q21. As a putative functional AR gene has been mapped to chromosome 7 and a putative pseudogene to chromosome 3, the sequences on the other seven chromosomes may represent other active genes, non-aldose reductase homologous sequences, or pseudogenes.