Incapacitating lower limb pain syndrome in cord blood stem cell transplant recipients with calcineurin inhibitor

Calcineurin-inhibitor induced pain syndrome (CIPS) is a newly described entity with a characteristic feature of sudden onset of severe lower limb pain, and high levels of cyclosporine or tacrolimus may be involved in the pathogenesis. This syndrome is rarely seen in recipients of hematopoietic stem...

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Bibliographic Details
Published inPathology oncology research Vol. 10; no. 4; pp. 204 - 206
Main Authors Kida, Aiko, Ohashi, Kazuteru, Kobayashii, Takeshi, Sakai, Miwa, Yamashita, Takuya, Akiyama, Hideki, Kishida, Shuji, Sakamaki, Hisashi
Format Journal Article
LanguageEnglish
Published Switzerland Springer Nature B.V 01.01.2004
Subjects
Adolescent
Adult
Blood
Calcineurin inhibitors
Cord blood
Cord Blood Stem Cell Transplantation
Cyclosporine - adverse effects
Cyclosporins
Diagnosis, Differential
Female
Hematopoietic stem cells
Humans
Immunosuppressive Agents - adverse effects
Leukemia - therapy
Lower Extremity - pathology
Male
Malignancy
Oncology
Pain
Pain - chemically induced
Pain - physiopathology
Pathology
Stem cell transplantation
Stem cells
Tacrolimus
Tacrolimus - adverse effects
Transplants & implants
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Summary:Calcineurin-inhibitor induced pain syndrome (CIPS) is a newly described entity with a characteristic feature of sudden onset of severe lower limb pain, and high levels of cyclosporine or tacrolimus may be involved in the pathogenesis. This syndrome is rarely seen in recipients of hematopoietic stem cell transplantation (HSCT) compared with other organ transplant recipients, however, heightened awareness of this complication after HSCT may be needed for hematologists, as misdiagnosis can result in catastrophic consequences. We report herein two cases of lower limb pain syndrome, with some clinical features resembling CIPS, occurring during the early phase of cord blood stem cell transplantation for hematological malignancy.
ISSN:1219-4956
1532-2807
DOI:10.1007/BF03033761