Age-dependent changes of postischemic reperfusion in rat skin

Ischemia-reperfusion plays a certain role in causing skin damage associated with pressure sores. In this study, changes in cutaneous hemodynamics during reperfusion were investigated in young and older rats. After cessation of 1-hour or 2-hour ischemia, the skin blood flow increased transiently (pos...

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Bibliographic Details
Published inAnnals of plastic surgery Vol. 50; no. 1; p. 64
Main Authors Inoue, Sadanori, Asai, Yasumasa, Kawai, Yasuaki
Format Journal Article
LanguageEnglish
Published United States 01.01.2003
Subjects
Aging - physiology
Animals
Blood Flow Velocity
Ischemia - physiopathology
Laser-Doppler Flowmetry
Male
Rats
Rats, Wistar
Reperfusion
Skin - blood supply
Surgical Flaps - blood supply
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Summary:Ischemia-reperfusion plays a certain role in causing skin damage associated with pressure sores. In this study, changes in cutaneous hemodynamics during reperfusion were investigated in young and older rats. After cessation of 1-hour or 2-hour ischemia, the skin blood flow increased transiently (postischemic hyperemia) and quickly returned to the baseline in young and older rats. After 4-hour ischemia, however, the postischemic hyperemia was reduced in both groups, and the skin blood flow decreased below the baseline for a few hours in older rats. The skin blood flow tolerated well the repeated exposures to 1-hour ischemia in both groups. In 2-hour ischemia experiments, the postischemic hyperemia was preserved after the second ischemic period in young rats but not in older rats. These results suggest that the tolerance of skin microcirculation to ischemia-reperfusion may decrease with increasing age.
ISSN:0148-7043
DOI:10.1097/00000637-200301000-00011