Catalysis of the disproportionation of superoxide by metalloporphyrins. III

An assay based on the use of an oxygen electrode has been used to determine the superoxide dismutase-type activity of several metalloporphyrins. Both the iron(III) and manganese(III) derivatives of tetrakis-(4- N-methylpyridyl)porphine were shown to have comparable activity, about 2-3% of that of th...

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Published inJournal of inorganic biochemistry Vol. 15; no. 3; pp. 261 - 267
Main Authors Pasternack, Robert F., Banth, Annelli, Pasternack, Jennifer M., Johnson, Christopher S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 1981
Subjects
Copper
Edetic Acid
Electrodes
Iron
Kinetics
Manganese
Metalloporphyrins
Oxygen
Superoxide Dismutase - metabolism
Superoxides
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Summary:An assay based on the use of an oxygen electrode has been used to determine the superoxide dismutase-type activity of several metalloporphyrins. Both the iron(III) and manganese(III) derivatives of tetrakis-(4- N-methylpyridyl)porphine were shown to have comparable activity, about 2-3% of that of the enzyme. Comparisons are made between this assay method and the more standard one which depends on the conversion of nitroblue tetrazolium to formazan.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0162-0134
1873-3344
DOI:10.1016/S0162-0134(00)80161-0