Aggressive oral carcinoma cuniculatum: A rare entity

• Published in: Journal of cancer research and therapeutics Vol. 18; no. 1; pp. 266 - 269
• Main Authors: Abilasha, J, Thankappan, Prasanth, Joseph, T, Angelin, D
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Subjects: Animals; Cancer; Cannibalism; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Carcinoma, Verrucous - pathology; Case studies; Head and Neck Neoplasms; Humans; Mouth cancer; Mouth Neoplasms - diagnosis; Rabbits; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; India; Cannibalism; immunohistochemistry; cuniculatum; E-cadherin
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.JCRT_161_20

Oral carcinoma cuniculatum (OCC) is a rare and distinct clinicopathological variant of oral squamous cell carcinoma (OSCC). The term cuniculatum was derived from a Latin word "cuniculus" meaning burrow, because of the "rabbit burrow" appearance. As it invades the underlying tissue, it forms crypts filled with keratin that are essential in distinguishing this neoplasm from other variants of squamous cell carcinoma (SCC). It is a common lesion of the plantar region of the foot but rare in the oral cavity. The first case of OCC was reported in 1977 by Flieger and Owenski in the jaw, with fewer than 50 cases reported in the English literature till date. Tumor cell cannibalism has been reported in various carcinomas such as lung, gallbladder, hepatobiliary, pancreatic, and SCC. Cell cannibalism when it refers to a cancer cell, either within a tumor mass or cell culture, is "a cell that is contained within another bigger cell with a crescent-shaped nucleus." This report aims to present a rare case of aggressive OCC of the maxillary gingiva with cellular cannibalism and its diverse immunohistochemical expression of E-cadherin, Ki-67, and p53.