Antioxidative effects of 7-hydroxy-3-methoxy-cadalene extracted from Zelkova serrata on 4-(methylinitros amino)-1-(3-pyridyl)-1-butanone-induced oxidative stress in A/J mice

• Published in: Phytotherapy research Vol. 18; no. 5; pp. 425 - 427
• Main Authors: Kim, J.H, Lee, H.J, Yeon, S.C, Choi, D.H, Lee, S.S, Kang, J.K, Chae, C.H, Paik, N.W, Lee, K.H, Cho, M.H
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.2004; Wiley
• Subjects: 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone; 7-hydroxy-3-methoxy-cadalene; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; antioxidant; antioxidant activity; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Biological and medical sciences; cadalene; Female; General pharmacology; gultathione; Lung Neoplasms - chemically induced; Lung Neoplasms - prevention & control; Medical sciences; medicinal plants; Mice; Mice, Inbred Strains; Nitrosamines; oxidative stress; Oxidative Stress - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; plant extracts; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; sesquiterpenoids; Specific Pathogen-Free Organisms; Ulmaceae; Zelkova serrata; Oxidative stress; 7-hydroxy-3-methoxy-cadalene; Lung; Rodentia; Oral administration; gultathione; Extract; Antioxidant; Respiratory system; Feeding; Vertebrata; Mammalia; Treatment; Diet; Mouse; Animal; 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone; Glutathione
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1427

Effects of 7‐hydroxy‐3‐methoxy‐cadalene (cadalene) extracted from Zelkova serrata on 4‐(methylinitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)‐induced oxidative stress were examined using A/J mice. NNK (65 µg/ml water) was orally administered to 20 mice for 7 weeks, followed by free feeding of a commercial diet, not containing cadalene, for 2 weeks. The control group was maintained without NNK and cadalene administration, and treatment groups with NNK and cadalene (6.25, 25, 100 mg/kg feed) feeding for 25 weeks. The glutathione concentration of cadalene‐treated (65 µg/ml water) group was significantly higher than that of the group treated only with NNK (p < 0.05). The results of our study strongly indicate that cadalene exerts antioxidative effect on NNK‐induced lung tumorigenesis in A/J mice. Copyright © 2004 John Wiley & Sons, Ltd.