Polydactyly and fetal hydantoin syndrome: an additional component of the syndrome?

• Published in: Clinical genetics Vol. 51; no. 5; pp. 343 - 345
• Main Authors: Yalçinkaya, Cengiz, Tüysüz, Beyhan, Somay, Göksel, Cenani, Asim
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.1997; Blackwell
• Subjects: Abnormalities, Drug-Induced; Abnormalities, Multiple - chemically induced; Biological and medical sciences; Child, Preschool; Craniofacial Abnormalities - chemically induced; Drug toxicity and drugs side effects treatment; Female; fetal hydantoin syndrome; Foot Deformities, Congenital - chemically induced; Growth Disorders - chemically induced; Humans; Intellectual Disability - chemically induced; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Pharmacology. Drug treatments; Phenytoin - adverse effects; Polydactyly; Polydactyly - chemically induced; Human; Toxicity; Diseases of the osteoarticular system; Dysostosis; Anticonvulsant; Congenital disease; Case study; Fetal diseases; Phenotype; Disease of the hand; Malformation; Polydactyly; Upper limb; Teratogen; Child
• ISSN: 0009-9163; 1399-0004
• DOI: 10.1111/j.1399-0004.1997.tb02485.x

We report a 3‐year‐old girl with fetal hydantoin syndrome (FHS) whose mother had received phenytoin 600 mg/day throughout gestation. She had growth retardation, mental deficiency, craniofacial dysmorphism and iris colomobata specific to FHS. However, the patient did not have the distal phalangeal hypoplasia which is associated with FHS; instead, she had Polydactyly of the right foot. This seems to be the first FHS case in the literature with Polydactyly.