Efficient electrochemical sensor for determination of H2O2 in human serum based on nano iron‑nickel alloy/carbon nanotubes/ionic liquid crystal composite

• Published in: Journal of electroanalytical chemistry (Lausanne, Switzerland) Vol. 881; p. 114953
• Main Authors: Atta, Nada F., Abdel Gawad, Soha A., Galal, Ahmed, Razik, Afaf Abdel, El-Gohary, Asmaa R.M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.01.2021; Elsevier Science Ltd
• Subjects: Amperometry; Blood; Blood serum sample; Buffer solutions; Carbon; Carbon nanotubes; Chemical sensors; Electrical measurement; Ferrous alloys; Glassy carbon; H2O2; Hydrogen peroxide; Ionic liquid crystal; Ionic liquids; Ions; Iron; Iron-nickel alloy; Liquid crystals; Nanoalloys; Nanoparticles; Nickel; Reduction; Sensors; Thin films; Carbon nanotubes; Amperometry; H2O2; Blood serum sample; Iron-nickel alloy; Ionic liquid crystal
• ISSN: 1572-6657; 1873-2569
• DOI: 10.1016/j.jelechem.2020.114953

A simple and efficient electrochemical sensor is presented for detecting H2O2 in human blood serum based on ionic liquid crystal (ILC), carbon nanotubes (CNTs) and Fe-Ni alloy nanoparticles modified glassy carbon electrode (GC). The sensor is fabricated by drop-casting two successive thin layers of ILC and (CNT-Fe-Ni) mixture over a GC surface; GC/ILC/(CNT-Fe-Ni). The synergism between the composite modifiers leads to excellent electrocatalytic activity toward H2O2 reduction in phosphate buffer solution with a well-identified reduction peak at −380 mV. The H2O2 conversion process is kinetically more favored over the sensor surface with a reduction current value of 178 μA compared to other studied modified electrodes. Amperometry determination of H2O2 in blood serum using the proposed sensor is achieved in a wide concentration range (0.007–1000 μM) and with low detection limit (0.971 nM). Practical application of the GC/ILC/(CNT-Fe-Ni) sensor is effectively assessed in human serum samples with acceptable recoveries, excellent anti-interference ability and long-term stability. [Display omitted] •Successive layers of (ILC), (CNTs) and Fe-Ni alloy nanoparticles used to fabricate a sensor.•The sensor determines H2O2 in presence of several compounds with low detection limits.•The DL and sensitivity for H2O2 sensing in plasma are 0.971 nM and 3.35 μA/μM.•The sensor components allow increase in ionic conductivity and electroactive surface area.•The sensor shows anti-interference ability for H2O2 with excellent recovery.