Investigation of ethyl alcohol and beta-carotene effect on two models of carcinogenesis

• Published in: Acta biologica Hungarica Vol. 54; no. 1; p. 89
• Main Authors: Uleckiene, Saule, Domkiene, Vida
• Format: Journal Article
• Language: English
• Published: Hungary 01.01.2003
• Subjects: Animals; Benzo(a)pyrene; beta Carotene - pharmacology; Carcinogens; Ethanol - pharmacology; Liver - drug effects; Liver - pathology; Lung Neoplasms - chemically induced; Lung Neoplasms - pathology; Mice; Mice, Inbred BALB C; Models, Animal; Skin Neoplasms - chemically induced; Skin Neoplasms - pathology; Urethane - toxicity
• DOI: 10.1556/ABiol.54.2003.1.9
• ISSN: 0236-5383

The effects of ethyl alcohol and synthetic beta-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose--100 mg/mouse) subcutaneous tumours were induced with locally acting benzo(a)pyrene (single injection, 2 mg/mouse) beta-Carotene was given 3 times per week 0.4 mg/mouse by gastric intubations and 10% ethanol was given instead of drinking water until the end of experiments (4-6 months). Results showed that beta-carotene did not significantly inhibit lung adenomogenesis and may moderately delay subcutaneous tumours occurence. In ourstudies chronic ethanol intake did notshow significant influence on this delay.