Investigation of ethyl alcohol and beta-carotene effect on two models of carcinogenesis

The effects of ethyl alcohol and synthetic beta-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose--100 mg/mouse) subcutaneous tumours were induced with locally acting benzo(...

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Bibliographic Details
Published inActa biologica Hungarica Vol. 54; no. 1; p. 89
Main Authors Uleckiene, Saule, Domkiene, Vida
Format Journal Article
LanguageEnglish
Published Hungary 01.01.2003
Subjects
Animals
Benzo(a)pyrene
beta Carotene - pharmacology
Carcinogens
Ethanol - pharmacology
Liver - drug effects
Liver - pathology
Lung Neoplasms - chemically induced
Lung Neoplasms - pathology
Mice
Mice, Inbred BALB C
Models, Animal
Skin Neoplasms - chemically induced
Skin Neoplasms - pathology
Urethane - toxicity
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Summary:The effects of ethyl alcohol and synthetic beta-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose--100 mg/mouse) subcutaneous tumours were induced with locally acting benzo(a)pyrene (single injection, 2 mg/mouse) beta-Carotene was given 3 times per week 0.4 mg/mouse by gastric intubations and 10% ethanol was given instead of drinking water until the end of experiments (4-6 months). Results showed that beta-carotene did not significantly inhibit lung adenomogenesis and may moderately delay subcutaneous tumours occurence. In ourstudies chronic ethanol intake did notshow significant influence on this delay.
ISSN:0236-5383
DOI:10.1556/ABiol.54.2003.1.9