Effect of new ethyl and methyl carbamates on Rhipicephalus microplus larvae and adult ticks resistant to conventional ixodicides

• Published in: Veterinary parasitology Vol. 199; no. 3-4; pp. 235 - 241
• Main Authors: Pérez-González, I E, Prado-Ochoa, M G, Muñoz-Guzmán, M A, Vázquez-Valadez, V H, Velázquez-Sánchez, A M, Avila-Suárez, B L, Cuenca-Verde, C, Angeles, E, Alba-Hurtado, F
• Format: Journal Article
• Language: English
• Published: Netherlands 31.01.2014
• Subjects: Acaricides - pharmacology; Animals; Carbamates - pharmacology; Drug Resistance - drug effects; Female; Ixodidae; Larva - drug effects; Oviposition - drug effects; Rhipicephalus; Rhipicephalus - drug effects; Urethane - pharmacology; Zygote - drug effects; Carbamates; Drug resistance; Rhipicephalus; Ticks; Ixodicides
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/j.vetpar.2013.07.042

The effects of six new synthetic carbamates on fully engorged females of four Rhipicephalus microplus strains (one reference strain susceptible to conventional ixodicides, two strains multiresistant to ixodicides and one tick field isolate) were compared. In addition, the effect of two other new synthetic carbamates was tested on larvae from the same strains. The first six tested carbamates reduced egg laying and inhibited egg hatching in the four studied strains (P<0.05). Compared with untreated females, the eggs produced by the treated engorged female ticks of all strains had a dark, dry, opaque appearance and were less adherent. The remaining two tested carbamates induced larval mortality in all of the evaluated strains. The three studied R. microplus strains displayed 50% resistance ratios (RR50) of less than 2 when compared to the susceptible reference strain. These results demonstrate that both carbamates with a larvicidal effect and carbamates that inhibit egg laying and embryo development are efficacious against tick strains that are resistant to commercial ixodicides, no cross resistance was observed.