Signet Ring Stromal Tumor of the Ovary Occurring in Conjunction with Brenner Tumor

• Published in: Gynecologic oncology Vol. 77; no. 2; pp. 323 - 326
• Main Authors: Cashell, Alan W., Jerome, W.Gray, Flores, Ernest
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2000
• Subjects: Brenner tumor; Brenner Tumor - pathology; Carcinoma, Signet Ring Cell - pathology; Female; Humans; Immunohistochemistry; Inhibins - analysis; Middle Aged; Ovarian Neoplasms - pathology; ovary; signet ring; stromal; tumor; signet ring; ovary; stromal; Brenner tumor; tumor
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1006/gyno.2000.5763

Objective. A case is presented of a single ovarian mass that had elements of both signet ring stromal tumor of the ovary and Brenner tumor. Methods. The histologic features and the results of histocytochemical, immunohistochemical, and electron microscopic studies are presented. Results. The signet ring component of the mass demonstrated features consistent with the few other cases previously reported. A positive immunohistochemical stain for the peptide hormone inhibin provides additional evidence for an ovarian stromal origin for this tumor. Conclusion. The tumor produced no hormonally related symptoms and has shown no evidence of recurrence. Signet ring stromal tumor of the ovary is an uncommon benign tumor that may be confused with metastatic signet ring carcinoma. The significance of the signet ring cells is not certain. Their association with Brenner tumor has not been previously described.