The Immunomodulatory Potential of Mesenchymal Stromal Cells: A Story of a Regulatory Network

Mesenchymal stromal cells (MSCs) have recently been the subject of great interest in the fields of regenerative medicine and immunotherapy due to their unique biological properties. In particular, MSCs possess immunoregulatory properties that can modulate immune as well as inflammatory responses. Al...

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Bibliographic Details
Published inJournal of immunotherapy (1997) Vol. 39; no. 2; p. 45
Main Authors Najar, Mehdi, Raicevic, Gordana, Crompot, Emerence, Fayyad-Kazan, Hussein, Bron, Dominique, Toungouz, Michel, Lagneaux, Laurence
Format Journal Article
LanguageEnglish
Published United States 01.02.2016
Subjects
Bone Marrow - immunology
Humans
Immune Tolerance
Immunomodulation
Immunotherapy
Interleukin-10 - metabolism
Mesenchymal Stromal Cells - immunology
Regenerative Medicine
Stromal Cells - immunology
T-Lymphocytes - immunology
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Summary:Mesenchymal stromal cells (MSCs) have recently been the subject of great interest in the fields of regenerative medicine and immunotherapy due to their unique biological properties. In particular, MSCs possess immunoregulatory properties that can modulate immune as well as inflammatory responses. Although there are many studies about MSC immunomodulation, several complex and conflicting mechanisms have been reported. Herein, we aim to review these mechanisms and identify a link between these pathways. We focus on human studies in which bone marrow-derived MSCs and T cells were investigated. We propose that MSC-induced immunomodulation exists as a network where converging regulatory pathways compete to establish a tolerogenic state. As interleukin-10 seems to play a central role in this network, we also discuss the relationship between this cytokine and other regulatory factors in the context of immunomodulation.
ISSN:1537-4513
DOI:10.1097/CJI.0000000000000108