Advantages of the CBA Mouse in Leukemogenesis Research

• Published in: Blood cells, molecules, & diseases Vol. 25; no. 1; pp. 38 - 45
• Main Authors: Rithidech, K.Noy, Cronkite, E.P., Bond, V.P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.1999
• Subjects: Acute Disease; Animals; Disease Models, Animal; Leukemia, Experimental - etiology; Leukemia, Experimental - genetics; Leukemia, Experimental - pathology; Leukemia, Myeloid - etiology; Leukemia, Myeloid - genetics; Leukemia, Myeloid - pathology; Leukemogenesis, radiation, benzene, cytogenetics; Male; Mice; Mice, Inbred CBA; Leukemogenesis, radiation, benzene, cytogenetics
• ISSN: 1079-9796; 1096-0961
• DOI: 10.1006/bcmd.1999.0225

The objectives of this review are to: (a) demonstrate that the male CBA/Ca mouse has several characteristics that make it an excellent animal for the study of leukemogenesis, (b) show that several of the genetic abnormalities observed in the male CBA/Ca mouse during the development of radiation induced acute myeloid leukemia (AML) are syntenic with those frequently detected in patients with myeloid disorders such as myelodysplastic syndrome and AML, (c) illustrate that leukemia-related chromosomal lesions are the indicators for high risk individuals.