MiRNA Biogenesis and Regulation of Diseases: An Overview

MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1509; p. 1
Main Authors Vishnoi, Anchal, Rani, Sweta
Format Journal Article
LanguageEnglish
Published United States 01.01.2017
Subjects
Animals
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Gene Expression
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs - biosynthesis
MicroRNAs - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Retinal Diseases - genetics
Retinal Diseases - metabolism
RNA Interference
Cardiovascular disease
miRNA
Neurodegenerative diseases
Cancer
Retinal disorder
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Summary:MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied for their role in biological processes as well as in development and progression of various human diseases including retinal disorder, neurodegenerative diseases, cardiovascular disease and cancer. This chapter summarises miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs holds huge potential for diagnostic and prognostic biomarkers, and as predictors of drug response.
ISSN:1940-6029
DOI:10.1007/978-1-4939-6524-3_1