Condensation of diethyl fluoromethylphosphonate with esters: An alternative synthetic route to diethyl α-fluoro-β-ketophosphonates
[Display omitted] •Base-induced condensation of diethyl fluoromethylphosphonate with esters.•New method for preparation of racemic diethyl α-fluoro-β-ketophosphonates.•Method is operationally simple and general for aryl, heteroaryl, and alkyl esters. New general and operationally simple method for p...
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Published in | Journal of fluorine chemistry Vol. 211; pp. 124 - 128 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
LAUSANNE
Elsevier B.V
01.07.2018
Elsevier Elsevier BV |
Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•Base-induced condensation of diethyl fluoromethylphosphonate with esters.•New method for preparation of racemic diethyl α-fluoro-β-ketophosphonates.•Method is operationally simple and general for aryl, heteroaryl, and alkyl esters.
New general and operationally simple method for preparation of racemic diethyl α-fluoro-β-ketophosphonates has been developed. Addition of LDA to solution of diethyl fluoromethylphosphonate and aromatic, heteroaromatic and aliphatic esters in THF at −78 °C afforded the corresponding diethyl α-fluoro-β-ketophosphonates in good to high yields. |
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ISSN: | 0022-1139 1873-3328 |
DOI: | 10.1016/j.jfluchem.2018.04.014 |