Kawasaki Disease with Peripheral and Facial Gangrene: A Case report and review of literature

With the onset of the SARS-CoV-2 pandemic, Kawasaki Disease (KD) has come to the fore with its many atypical manifestations. Atypical clinical neurological, ophthalmological, musculoskeletal, gastrointestinal and pulmonary manifestations in a febrile child with raised markers should prompt the clini...

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Published inTropical doctor p. 494755221081598
Main Authors Madan, Dolly, Maheshwari, Anu, Mahto, Deonath, Mendiratta, Vibhu, Sharma, Sunita
Format Journal Article
LanguageEnglish
Published England 01.07.2022
Subjects
Gangrene
IVIG
Kawasaki disease
purpura fulminans
infliximab
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Summary:With the onset of the SARS-CoV-2 pandemic, Kawasaki Disease (KD) has come to the fore with its many atypical manifestations. Atypical clinical neurological, ophthalmological, musculoskeletal, gastrointestinal and pulmonary manifestations in a febrile child with raised markers should prompt the clinician to think of Kawasaki disease. Peripheral gangrene is a rare atypical manifestation of KD reported in infancy. We present a three-and-a-half-year-old boy with extensive gangrene all four limbs and face along with purpura fulminans. He was successfully treated with two doses of intravenous immunoglobulin (IVIG) and infliximab, with no residual gangrene. This case highlights that very severe forms of Kawasaki disease require IVIG, pulse steroids as well as infliximab for adequate control and complete resolution of the disease.
ISSN:1758-1133
DOI:10.1177/00494755221081598