A PRELIMINARY EVALUATION OF ANTIFERTILITY ACTIVITY OF A TRITERPENOID GLYCOSIDE (DSS) FROM DALBERGIA SAXATILIS IN FEMALE WISTAR RATS

Antifertility activity of a triterpenoid glycoside, DSS, isolated from the root of Dalbergia saxatilis was investigated in female Wistar rats of breeding age. When administered by gastric intubation at a dose rate of 200 mg kg−1body weight at the premating period, conception was inhibited in 71.4% o...

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Published inPharmacological research Vol. 41; no. 5; pp. 521 - 525
Main Authors UCHENDU, C.N., KAMALU, T.N., ASUZU, I.U.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.05.2000
Subjects
Animals
DSS, fertility, pregnancy, trimester, rat
Estrus - drug effects
Female
Fertility - drug effects
Glycosides - pharmacology
Pregnancy
Rats
Rats, Wistar
Triterpenes - pharmacology
DSS, fertility, pregnancy, trimester, rat
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Summary:Antifertility activity of a triterpenoid glycoside, DSS, isolated from the root of Dalbergia saxatilis was investigated in female Wistar rats of breeding age. When administered by gastric intubation at a dose rate of 200 mg kg−1body weight at the premating period, conception was inhibited in 71.4% of the treated animals. Fertility Index (FI) for this group was 107.82 compared with 373.5 value for control rats that received 30% aqueous Tween 20 vehicle. DSS, did not significantly alter the fertility of rats at the first and second trimesters of pregnancy but did cause a significant decrease (P<0.05) in the mean Day 20 foetal crown-rump length when administered at the premating period and at the third trimester of pregnancy; with a concurrent decline in the mean maternal body weights. The potential use of DSS as a chemosterilant in fertility control are discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1999.0615