Effect of L-valine impurity on the nucleation parameters of aqueous L-glutamic acid solutions from metastable zone width data

•Effect of L-valine on metastable zone width of aqueous L-glutamic acid solutions is studied.•Nucleation parameters are determined from MSZW data using different models.•The value of interfacial energy increases with impurity concentration.•MSZW of L-glutamic acid solutions is associated with hetero...

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Bibliographic Details
Published inJournal of crystal growth Vol. 546; p. 125790
Main Authors Shiau, Lie-Ding, Wu, Dai-Rong
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.09.2020
Elsevier BV
Subjects
A1. Crystallites
A1. Impurities
A1. Metastable zone width
A1. Nucleation parameters
Cooling rate
Glutamic acid
Impurities
Interfacial energy
Nucleation
Valine
A1. Crystallites
A1. Metastable zone width
A1. Nucleation parameters
A1. Impurities
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Summary:•Effect of L-valine on metastable zone width of aqueous L-glutamic acid solutions is studied.•Nucleation parameters are determined from MSZW data using different models.•The value of interfacial energy increases with impurity concentration.•MSZW of L-glutamic acid solutions is associated with heterogeneous nucleation. Effect of L-valine on the metastable zone width (MSZW) of aqueous L-glutamic acid solutions saturated at 45 °C at various cooling rates was studied and examined by using various models based on the classical nucleation theory. From the MSZW data for each impurity concentration, values of the pre-exponential nucleation factor and interfacial energy were determined and discussed. It was found that the value of MSZW of the aqueous L-glutamic acid solutions is associated with heterogeneous nucleation and the value of the interfacial energy increases with impurity concentration.
ISSN:0022-0248
1873-5002
DOI:10.1016/j.jcrysgro.2020.125790