The pharmacokinetics of promethazine after intravenous administration in camels

The pharmacokinetics of promethazine were determined in seven camels (Camelus dromedarius) after an intravenous dose of 0·5 mg kg body weight.–1The data obtained (median and range) were as follows: the elimination half-life (t1/2β) was 5·62 (2·84–6·51) h; the steady state volume of distribution (Vds...

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Published inResearch in veterinary science Vol. 66; no. 2; pp. 159 - 160
Main Authors WASFI, I.A, BAREZAIQ, I.M, ALKATHEERI, N, HADI, A.A.A, BONI, N.S, ALMUHRAMI, A.M, ELGHAZALI, M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1999
Subjects
Animals
Camelus
Half-Life
Histamine H1 Antagonists - administration & dosage
Histamine H1 Antagonists - blood
Histamine H1 Antagonists - pharmacokinetics
Injections, Intravenous
Male
Metabolic Clearance Rate
Promethazine - administration & dosage
Promethazine - blood
Promethazine - pharmacokinetics
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Summary:The pharmacokinetics of promethazine were determined in seven camels (Camelus dromedarius) after an intravenous dose of 0·5 mg kg body weight.–1The data obtained (median and range) were as follows: the elimination half-life (t1/2β) was 5·62 (2·84–6·51) h; the steady state volume of distribution (Vdss) was 8·90 (7·10–12·00) L kg–1, total body clearance (CT) was 24·5 (17·22–33·65) ml kg–1min–1and renal clearance (Clr) was 4·81 (1·97–5·48) ml kg–1min–1
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0034-5288
1532-2661
DOI:10.1053/rvsc.1998.0255