Problematic clinical trials in thyroid cancer: the issue of papillary carcinoma and observational approaches

We describe the clinical ethics problem of American thyroid cancer patients being offered 'observation' instead of the USA standard of care with questionable informed consent. This problem arose because some American practitioners misinterpreted 1990s Japanese studies. American proponents...

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Bibliographic Details
Published inInternational Journal of Endocrine Oncology Vol. 4; no. 3; pp. 127 - 136
Main Authors Rosenthal, M Sara, Ain, Kenneth B, Angelos, Peter, Hatanaka, Ryoko, Motojima, Masaru
Format Journal Article
LanguageEnglish
Japanese
Published London Future Medicine Ltd 01.08.2017
Informa UK Limited
Subjects
Blood & organ donations
Cancer therapies
Cervical cancer
clinical ethics
clinical trials
Diabetes
Ethics
Human subjects
Hypertension
Iodine
Lymphatic system
Medical prognosis
Metastasis
observational protocols
Research ethics
Surgery
Surveillance
Thyroid cancer
Tumors
United States > US
Japan
India
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Summary:We describe the clinical ethics problem of American thyroid cancer patients being offered 'observation' instead of the USA standard of care with questionable informed consent. This problem arose because some American practitioners misinterpreted 1990s Japanese studies. American proponents of these studies failed to recognize major differences in ethical oversight between Japanese and US clinical research, misrepresenting these studies as justifying clinical practices for higher risk patients that were not supported by data. The current professional environment in American thyroid cancer management is sufficiently problematic that consideration should be made, for patients who have inadvertently consented to nonevidence-based treatments, to be recontacted and provided an opportunity to revisit their care plans or seek second opinions regarding an observational approach.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2045-0869
2045-0877
DOI:10.2217/ije-2017-0008