Leptin deficiency due to lipid apheresis: a possible reason for ravenous hunger and weight gain

• Published in: International Journal of Obesity Vol. 24; no. 2; pp. 259 - 260
• Main Authors: Leitner, G.C, Roob, J.M, Bahadori, B, Wallner, S, Wascher, T.C
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01.02.2000; Nature Publishing Group
• Subjects: Apheresis; Biological and medical sciences; blood glucose; Blood Glucose - analysis; blood serum; Body fat; case studies; Cholesterol; Cholesterol - blood; Cholesterol, LDL - blood; diurnal variation; energy intake; Energy Intake - physiology; Food; food intake; food records; Humans; Hunger; Hyperlipidemias - blood; Hyperlipidemias - therapy; Internal medicine; leptin; Leptin - blood; Leptin - deficiency; Lipids; Low density lipoprotein; low density lipoprotein cholesterol; Male; males; Medical sciences; Metabolic diseases; Middle Aged; Nephrology; Obesity; pathogenesis; patients; Physiology; Plasmapheresis - adverse effects; radioimmunoassays; renal failure; therapeutics; Weight control; Weight Gain; White people; Missouri; United States > US; Austria; Germany; Endocrinopathy; Kidney disease; Appetite; Human; Obesity; Urinary system disease; Apheresis; Deficiency; Nutrition disorder; Extracorporeal circuit; Weight gain; Cholesterol; Leptin; Renal failure; Nutritional status
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0801160

OBJECTIVE: To investigate how extracorporal cholesterol lowering therapy affects circulating leptin levels in patients with ravenous hunger after treatment and permanent weight gain. DESIGN: A case report. SUBJECT: 51 y old caucasian male patient with moderate chronic renal failure. MEASUREMENTS: Serum Leptin concentration (RIA, Linco Research Inc, St. Louis, MO, USA), total cholesterol, low density lipoprotein cholesterol, blood glucose levels, calorie intake by food records. RESULTS: During treatment total cholesterol was reduced by 50%. Serum Leptin levels showed a 42% reduction at the end of treatment, that by far exceeds the physiological diurnal variation. Calorie intake was significantly increased on days of treatment. CONCLUSION: We conclude that this artificial reduction in circulating leptin plays an important role in the pathogenesis of ravenous hunger and weight gain under extracorporal cholesterol lowering therapy in this case.