Complications After Pancreaticoduodenectomy for Pancreatic Cancer: A Retrospective Study

• Published in: International surgery Vol. 96; no. 3; pp. 220 - 227
• Main Authors: Ren, Shiyan, Liu, Peng, Zhou, Ningxin, Dong, Jiahong, Liu, Rong, Ji, Wenbin
• Format: Journal Article
• Language: English
• Published: Chicago, IL International College of Surgeons 01.07.2011
• Subjects: Biological and medical sciences; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Logistic Models; Male; Medical sciences; Multivariate Analysis; Pancreatic Ducts - pathology; Pancreatic Fistula - epidemiology; Pancreatic Fistula - mortality; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - surgery; Pancreaticoduodenectomy - adverse effects; Postoperative Complications - epidemiology; Retrospective Studies; Risk Factors; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Tumors; Duodenum; Digestive system; Fistula; Retrospective study; Malignant tumor; Pancreaticoduodenectomy; Small intestine; Treatment; Surgery; Pancreatic cancer; Pancreas cancer; Digestive diseases; Complication; Pancreas; Pancreatic fistula; Cancer; Pancreatic disease; Pancreatoduodenectomy
• ISSN: 0020-8868; 2520-2456
• DOI: 10.9738/CC17.1

Postoperative complications, such as pancreatic fistulae, after pancreaticoduodenectomy for pancreatic cancers are associated with surgical outcomes of patients with pancreatic cancers. A total of 160 patients with pancreatic cancers undergoing pancreaticoduodenectomy were retrospectively analyzed. Patients were grouped into a fistulae group (n = 34) and a nonfistulae group (n = 126). The fistulae group had a significantly higher morbidity rate than the nonfistulae group (P < 0.0001), but hospital mortality was not different in both groups (P = 0.481). There was a higher incidence of intra-abdominal hemorrhage in patients with pancreatic fistulae than in those without fistulae. Two patients in fistulae group underwent reoperation. Patients with pancreatic fistulae had significantly longer hospital stay than those without fistulae. Pancreatic duct diameter, smoking, years of tobaccos consumption, preoperative jaundice, and surgical hours were associated with risk of fistulae on univariate analysis. In a multivariate analysis, diameter of pancreatic duct, surgical hours, and preoperative jaundice were independent risk factors of pancreatic fistulae. Incidence of pancreatic fistulae after pancreaticoduodenectomy is significantly influenced by the size of pancreatic duct diameter, surgical time, and preoperative jaundice. Early postoperative hemorrhage could be cautiously prevented. The survival is not significantly impacted by pancreatic fistulae.