A catalytic method for the reduction of secondary and tertiary phosphine oxides

TMDS has been found to be an efficient hydride source for the reduction of tertiary and secondary phosphine oxides using a catalytic amount of Ti(Oi-Pr)(4). All classes of tertiary phosphine oxides, such as triaryl, trialkyl, and diphosphine, were effectively reduced.

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Bibliographic Details
Published inSynlett no. 10; pp. 1545 - 1548
Main Authors Berthod, Mikael, Favre-Reguillon, Alain, Mohamad, Jahjah, Mignani, Gerard, Docherty, Gordon, Lemaire, Marc
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 18.06.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SYSTEM
HYDROGENATION
reductions
titanium
TRIPHENYLPHOSPHINE
BORANES
STEREOSPECIFIC DEOXYGENATION
phosphine oxides
ALCOHOLS
BINAP
hydrosiloxane
REDUCING AGENT
LITHIUM ALUMINUM-HYDRIDE
LIGAND
phosphorus
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Summary:TMDS has been found to be an efficient hydride source for the reduction of tertiary and secondary phosphine oxides using a catalytic amount of Ti(Oi-Pr)(4). All classes of tertiary phosphine oxides, such as triaryl, trialkyl, and diphosphine, were effectively reduced.
ISSN:0936-5214
DOI:10.1055/s-2007-982536