Indocyanine green angiography of choroidal tumors

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 233; no. 11; p. 677
• Main Authors: Sallet, G, Amoaku, W M, Lafaut, B A, Brabant, P, De Laey, J J
• Format: Journal Article
• Language: English
• Published: Germany 01.11.1995
• Subjects: Choroid Neoplasms - diagnosis; Fluorescein Angiography - methods; Fundus Oculi; Hemangioma - diagnosis; Humans; Indocyanine Green; Melanoma - diagnosis; Nevus, Pigmented - diagnosis; Skin Neoplasms - diagnosis
• ISSN: 0721-832X
• DOI: 10.1007/bf00164669

Fluorescein angiography (FA) has been widely used in the diagnostic evaluation of choroidal tumors. Indocyanine green angiography (ICG-A), which permits better visualization of choroidal vasculature than FA, has been recently introduced into clinical practice. Only few reports exist on the ICG-A characteristics of choroidal tumors. The fluorescein and indocyanine green angiograms of 61 patients were assessed. These included 14 patients with choroidal nevi, 30 with malignant melanomas, 7 with suspected melanomas or atypical nevi, 5 with hemangiomas and 5 with metastases. The outline of pigmented tumors was more accurate on ICG-A than on FA. Characteristic patterns were seen in all intra-ocular tumors with ICG-A, so it was possible to distinguish hemangiomas from malignant lesions. Characteristic features of malignant melanomas include abnormal vascular pattern and marginal late dye leakage. None of the benign lesions showed these features. In suspected melanomas, the presence of abnormal choroidal vascular patterns and/or late dye leakage on ICG-A may indicate malignancy. The study suggests that ICG-A can yield additional information that is useful in differentiating amongst choroidal tumors. Better delineation of pigmented lesions with ICG-A allows more accurate treatment planning and follow-up.