Intravenous colchicine for low-back pain: a double-blind study

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 15; no. 7; p. 716
• Main Authors: Simmons, J W, Harris, W P, Koulisis, C W, Kimmich, S J
• Format: Journal Article
• Language: English
• Published: United States 01.07.1990
• Subjects: Adult; Back Pain - drug therapy; Colchicine - administration & dosage; Colchicine - therapeutic use; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Prospective Studies
• ISSN: 0362-2436
• DOI: 10.1097/00007632-199007000-00018

Colchicine, a drug used for centuries in the treatment of gout, has been reported to be effective for low-back pain due to disc disorders. A prospective, randomized, double-blind study evaluating the therapeutic effect of intravenous colchicine was conducted in a group of patients with low-back pain with symptoms originating less than 6 months previously. Each patient completed a questionnaire and a pain drawing. Laboratory studies including uric acid and sedimentation rate were performed, as was a detailed physical examination and lumbar thermography. All treatment parameters (including physical therapy, anti-inflammatory medications, and instructions) were constant except that each patient received either intravenous colchicine or intravenous saline. Results indicate a significant difference between the two groups, the intravenous colchicine group showing improvement in symptoms for a few hours or days over a 3-week course of treatment. However, the relief was often of short duration.