Itraconazole Coated Super Paramagnetic Iron Oxide Nanoparticles for Antimicrobial Studies

• Published in: Biointerface Research in Applied Chemistry Vol. 10; no. 5; pp. 6218 - 6225
• Format: Journal Article
• Language: English
• Published: 15.10.2020
• ISSN: 2069-5837; 2069-5837
• DOI: 10.33263/BRIAC105.62186225

In this present study, Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were produced using FeCl3 and FeCl2 which were reduced to iron oxides using NaOH and ammonia solution (chemical co-precipitation). These naked SPIONs were further fabricated to form drug laden core-shell for controlled drug release and delivery. The fabrication was achieved by subjugating the naked SPIONs for oleic acid functionalization, drug tagging (Itraconazole) and finally encapsulated with a microbial derived polyester namely Polyhydroxybutyrate (PHB). Every stage of fabrication was characterized by scanning electron microscopy (SEM). The core-shell produced was checked for drug release kinetics, antibacterial and antifungal activities. These synthesized core-shells were carrying the drug and showed a slow drug release profile. The antimicrobial studies against bacteria - Pseudomonas aeruginosa & Brevibacillus brevis and fungi - Candida albicans by diffusion method proved that the core-shells inhibited bacterial and fungal activity. Furthermore, the naked SPIONs was found to be a good contrasting agent in X-ray imaging.