Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia

The methanol fraction of an ethanolic extract from the roots of Polygala tenuifolia Willd. showed antagonistic action on neurotoxicity induced by glutamate and serum deficiency in PC12 cells. Bioassay-guided fractionation led to the isolation of six new triterpenoid saponins, onjisaponins V - Z, and...

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Bibliographic Details
Published inPlanta medica Vol. 74; no. 2; pp. 133 - 141
Main Authors Li, C, Yang, J, Yu, S, Chen, N, Xue, W, Hu, J, Zhang, D
Format Journal Article
LanguageEnglish
Published Germany 01.02.2008
Subjects
Animals
Cell Survival - drug effects
chemical structure
Culture Media
cultured cells
human health
Hydrolysis
medicinal plants
medicinal properties
Medicine, Chinese Traditional
Neuroprotective Agents - pharmacology
neuroprotective effect
onjisaponin
Oriental traditional medicine
PC12 Cells
phytochemicals
Plant Roots - chemistry
Polygala
Polygala - chemistry
Polygala tenuifolia
Polygalaceae
Rats
root systems
Saponins - isolation & purification
Saponins - pharmacology
spectral analysis
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoid saponins
China
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Summary:The methanol fraction of an ethanolic extract from the roots of Polygala tenuifolia Willd. showed antagonistic action on neurotoxicity induced by glutamate and serum deficiency in PC12 cells. Bioassay-guided fractionation led to the isolation of six new triterpenoid saponins, onjisaponins V - Z, and Vg ( 1 - 6), together with ten known saponins ( 7 - 16). The structures of 1 - 6 were elucidated by spectroscopic and chemical methods. Screening results indicated that compounds 1 - 16 showed neuroprotective effects against serum deficiency and glutamate at the concentration of 10 (-5) mol/L.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2008-1034296