Facile generation of a library of 5-aryl-2-arylsulfonyl-1,3-thiazoles

Treatment of N,N-diformylaminomethyl aryl ketones with phosphorus pentasulfide/triethylamine in chloroform gives 5-arylthiazoles directly in good yield. The 5-aryl-1,3-thiazole core has been successfully functionalised at the 2-position to yield, over two steps, a large array of 5-aryl-2-arylsulfony...

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Bibliographic Details
Published inSynlett no. 3; pp. 460 - 462
Main Authors Sheldrake, PW, Matteucci, M, McDonald, E
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 15.02.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
POTENT
heterocycles
SUBSTITUTED THIAZOLES
1,3-thiazole
lithiation
INHIBITORS
phosphorus pentasulfide
CATALYZED ARYLATION
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Summary:Treatment of N,N-diformylaminomethyl aryl ketones with phosphorus pentasulfide/triethylamine in chloroform gives 5-arylthiazoles directly in good yield. The 5-aryl-1,3-thiazole core has been successfully functionalised at the 2-position to yield, over two steps, a large array of 5-aryl-2-arylsulfonyl-1,3-thiazoles in a parallel fashion.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-926243