The role of γ-aminobutyric acid and its receptors in the nucleus of basal optic root in pigeons

The effects of γ-aminobutyric acid (GABA) and its antagonists bicuculline and 2-hydroxysaclofen on neuronal firings in the nucleus of basal optic root (nBOR) in pigeons were studied by using extracellular recording and microiontophoretic techniques. The results suggest that GABA may be an inhibitory...

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Published inScience China. Life sciences Vol. 40; no. 3; pp. 264 - 269
Main Author 付煜西 高宏峰 王书荣 Stephen A.George
Format Journal Article
LanguageEnglish
Published China Springer Nature B.V 01.06.1997
Subjects
acid
Antagonists
basal
Bicuculline
GABA
inhibition
microiontophoresis
nBOR
nucleus
optic
pigeon
receptor
root
γ-aminobutyric
γ-Aminobutyric acid A receptors
γ-Aminobutyric acid B receptors
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ISSN1674-7305
1006-9305
1869-1889
1862-2798
DOI10.1007/BF02879086

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Summary:The effects of γ-aminobutyric acid (GABA) and its antagonists bicuculline and 2-hydroxysaclofen on neuronal firings in the nucleus of basal optic root (nBOR) in pigeons were studied by using extracellular recording and microiontophoretic techniques. The results suggest that GABA may be an inhibitory neurotransmitter or modulator within nBOR, functioning by means of main mediation of GABAA receptors and of minor mediation of GABAB receptors. Furthermore, GABA and its GABAA receptors are involved in the modulation of directional selectivity in part of nBOR neurons.
Bibliography:FU Yuxi , GAO Hongfeng , Stephen A. Georgeand WANG Shurong(Laboratory for Visual Information Processing, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China)
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ISSN:1674-7305
1006-9305
1869-1889
1862-2798
DOI:10.1007/BF02879086