Abnormal Urinary Steroid Profiles in Four Hypertensive Obese Children
There is a poorly understood association between obesity and hypertension. We demonstrated abnormalities of adrenal androgen and cortisol metabolites in four hypertensive obese children. Four males (aged 10 to 15 years) were evaluated for systolic blood pressures consistently above the 99.6th percen...
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Published in | Journal of Pediatric Endocrinology and Metabolism Vol. 23; no. 3; pp. 237 - 244 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Germany
De Gruyter
01.03.2010
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Subjects | |
Online Access | Get full text |
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Summary: | There is a poorly understood association between obesity and hypertension. We demonstrated abnormalities of adrenal androgen and cortisol metabolites in four hypertensive obese children.
Four males (aged 10 to 15 years) were evaluated for systolic blood pressures consistently above the 99.6th percentile. All were overweight with BMI ranging from 27-35. Clinical examinations, renal ultrasound and DMSA scans were normal. Plasma electrolytes, renin, aldosterone, cortisol, testosterone, ACTH and TSH were normal. 24-Hour urinary steroid profiles showed a generalised excess of adrenal androgen and cortisol metabolites in all cases. Relevant recognised disorders of adrenal androgen and cortisol metabolism were excluded.
There is no clinical condition explaining these abnormal urinary steroid profiles. These results support previous findings and provide new data on abnormal urinary adrenal androgen excretion in obese hypertensive patients. Further studies may determine the relationship between obesity, hypertension and the observed abnormalities of urinary steroid excretion. |
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Bibliography: | istex:6EE9B5BBDCCEE69D5263F63B4844CE76467289E9 ArticleID:JPEM.2010.23.3.237 jpem.2010.23.3.237.pdf ark:/67375/QT4-XM5MZD1G-B ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0334-018X 2191-0251 |
DOI: | 10.1515/JPEM.2010.23.3.237 |