Developing a novel magnesium calcium phosphate/sodium alginate composite cement with high strength and proper self-setting time for bone repair

• Published in: Journal of biomaterials applications Vol. 36; no. 2; p. 346
• Main Authors: He, Haosheng, Ren, Haohao, Ding, Zhengwen, Ji, Mizhi, Chen, Hong, Yan, Yonggang
• Format: Journal Article
• Language: English
• Published: England 01.08.2021
• Subjects: Alginates - chemistry; Animals; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Bone Cements - chemistry; Bone Cements - pharmacology; Cell Differentiation - drug effects; Cell Line; Cell Proliferation - drug effects; Compressive Strength; Hydrogen-Ion Concentration; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mice; Phosphates - chemistry; sodium alginate; Magnesium calcium phosphate; composite bone cement; high compressive strength
• ISSN: 1530-8022
• DOI: 10.1177/08853282211021535

In this work, novel magnesium calcium phosphate/sodium alginate composite cements were successfully fabricated with a proper setting time (5-24 min) and high compressive strength (91.1 MPa). The physicochemical and biological properties of the cement in vitro were fully characterized. The composite cements could gradually degrade in PBS as the soaking time increase, and the weight loss reached 20.74% by the end of 56th day. The cements could induce the deposition of Ca-P layer in SBF. Cell experiments proved that the extracts of the composite cements can effectively promote the proliferation and differentiation of the mouse bone marrow mesenchymal stem cells (MSCs). These preliminary results indicate that the magnesium calcium phosphate/sodium alginate composite cements could be promising as potential bone repair candidate materials.