Paraneoplastic limbic encephalitis and possible narcolepsy in a patient with testicular cancer: case study

We describe a patient who presented with a clinical syndrome of limbic encephalitis, narcolepsy, and cataplexy. The anti-Ma2 antibody was positive. Although there was no mass on imaging, orchiectomy was performed in this patient, and testicular carcinoma was found. This is the first known case of li...

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Bibliographic Details
Published inNeuro-oncology (Charlottesville, Va.) Vol. 5; no. 3; pp. 214 - 216
Main Authors Landolfi, Joseph C, Nadkarni, Mangala
Format Journal Article
LanguageEnglish
Published England 01.07.2003
Subjects
Adult
Diagnosis, Differential
Humans
Limbic Encephalitis - complications
Limbic Encephalitis - diagnosis
Male
Narcolepsy - complications
Narcolepsy - diagnosis
Testicular Neoplasms - complications
Testicular Neoplasms - diagnosis
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Summary:We describe a patient who presented with a clinical syndrome of limbic encephalitis, narcolepsy, and cataplexy. The anti-Ma2 antibody was positive. Although there was no mass on imaging, orchiectomy was performed in this patient, and testicular carcinoma was found. This is the first known case of limbic encephalitis and anti-Ma2 antibody to be associated with cataplexy and possible narcolepsy. Neurological symptoms precede the diagnosis of cancer in 50% of patients with paraneoplastic syndromes, and clinicians are therefore strongly advised to evaluate patients with neurological symptoms for this condition.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:1522-8517
1523-5866
DOI:10.1215/S1152851702000467