Mitotic bookmarking by transcription factors: be aware of redundancy

A recent report by Chervova, Molliex, et al. shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division,...

Full description

Saved in:
Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 49; no. 5; pp. 384 - 386
Main Authors Silva, Miguel V., Castro, Diogo S.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2024
Subjects
Animals
cell identity
chromatin
Chromatin - metabolism
Humans
Mice
Mitosis
mitotic bookmarking by transcription factors
Mouse Embryonic Stem Cells - cytology
Mouse Embryonic Stem Cells - metabolism
nuclear receptors
pluripotency network
Receptors, Estrogen
transcription
Transcription Factors - metabolism
nuclear receptors
mitotic bookmarking by transcription factors
cell identity
transcription
pluripotency network
Online AccessGet full text

Cover

More Information
Summary:A recent report by Chervova, Molliex, et al. shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency. A recent report by Chervova, Molliex, et al. shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2024.03.003