Synthesis, physicochemical and biological studies of a ternary Co(II) complex with sulfaquinoxaline and 2,2′-bipyrimidine as ligands

• Published in: Inorganica Chimica Acta Vol. 447; pp. 127 - 133
• Main Authors: Villa-Pérez, C., Cadavid-Vargas, J.F., Camí, G.E., Giannini, F., Chacón Villalba, M.E., Echeverria, G., Ortega, I.C., Valencia-Uribe, G.C., Etcheverry, S.B., Soria, D.B.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2016
• Subjects: 2,2′-Bipyrimidine; Biological properties; Co(II) complex; Spectroscopic properties; Sulfaquinoxaline; X-ray structure; Biological properties; Spectroscopic properties; 2,2′-Bipyrimidine; Co(II) complex; X-ray structure; Sulfaquinoxaline
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2016.03.043

Biological, spectroscopic and structural studies of a complex of Cobalt(II) with sulfaquinoxaline and 2,2′-bipyridine as ligands were carried out. Cytotoxicity was studied in the human osteosarcoma cell line (MG-63). Antibactericidal capacity was tested against four strains (Gram positive and negative bacteria). The aquatic toxicity was tested on two fish species. [Display omitted] •A complex of Cobalt(II) with sulfaquinoxaline and Bpym as ligands has been prepared.•The complex has been characterized based on FTIR and Raman spectroscopy.•The aquatic toxicity was evaluated on the Danio rerio y Cyprinus carpio haematopterus.•Antibacterial activity was screened: E. coli, S. typhimurium, S. aureus and B. cereus.•The antiproliferative effect was studied in the human osteoblast MG-63 cell line. A novel ternary complex of Cobalt(II) with 4-amino-N-2-quinoxalinylbenzenesulfonamide (sulfaquinoxaline, SQO), and 2,2′-bipyrimidine (Bpym) as ligands has been prepared. The complex has been characterized based on elemental analyses, FTIR and Raman spectroscopy. Its structure, [Co(SQO)2(Bpym)] was determined by X-ray diffraction methods. It crystallizes in the triclinic P1¯ space group with a=10.5381(2), b=13.6469(2), c=13.8409(3)Å, α=95.058(2)°, β=93.769(2)°, γ=93.750(2)° and Z=2 molecules per unit cell. Thermogravimetric (TG) and differential thermal analysis (DT) were also studied. The aquatic toxicity of the complex was evaluated on the two following test organisms: Danio rerio (cebritas) y Cyprinus carpio haematopterus (carpas koi). Antibacterial activity was screened against Escherichia coli (ATCC 8739), Salmonella typhimurium (ATCC 14028), Staphylococcus aureus (ATCC 49775) and Bacillus cereus (ATCC 10987). The antiproliferative effect of the tested complex [Co(SQO)2(Bpym)] in the human osteoblast (MG-63) cell line was also studied.