CYP2C19 Gene Polymorphism May Be a Risk Factor for Bronchial Asthma

• Published in: Medical principles and practice Vol. 20; no. 1; pp. 39 - 42
• Main Authors: Yildirim Yaroğlu, Hatice, Çalıkoğlu, Mukadder, Tamer Gümüş, Lülüfer
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2011
• Subjects: Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases - genetics; Asthma - diagnosis; Asthma - epidemiology; Asthma - genetics; Case-Control Studies; Cytochrome P-450 CYP2C19; Female; Genetic Predisposition to Disease; Heterozygote; Humans; Logistic Models; Male; Middle Aged; Original Paper; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Turkey - epidemiology; Young Adult; CYP2C19; Gene polymorphism; Asthma
• ISSN: 1011-7571; 1423-0151
• DOI: 10.1159/000322077

Objective: The aim of the present study was to investigate whether the genetic polymorphism of CYP2C19 plays a role in susceptibility to bronchial asthma. Subjectsand Methods: 104 healthy individuals who visited our hospital, including hospital staff, and 97 patients with bronchial asthma (62 atopic and 35 nonatopic) participated in this study. CYPC19*2 and CYP21C9*3 alleles were detected by using LightCycler and CYP2C19 mutation detection kits by real-time PCR with LightCycler. Results: The CYP2C19*3 genotype was found to be the wild type in all cases, and in the control group, the CYP2C19*2 heterozygous genotype had a 2.46-fold increased risk of bronchial asthmacompared with the CYPC19*2 homozygous wild genotype in the control group(p = 0.01, OR = 2.46, 95% CI 1.24–4.88). Conclusion: Our data suggest that the CYP2C19*2 heterozygous genotype may be involved in the development of bronchial asthma.