Asymmetric hydrogenation of 2,3-dihydro-1H-inden-1-one oxime and derivatives

[Display omitted] Asymmetric hydrogenation of 2,3-dihydro-1H-inden-1-one oxime and derivatives to produce the corresponding optically active amine has been performed in the presence of rhodium and iridium catalysts. The optimization of neutral rhodium based catalytic systems by varying the operating...

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 27; no. 6; pp. 268 - 273
Main Authors Maj, Anna M., Suisse, Isabelle, Agbossou-Niedercorn, Francine
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.04.2016
Elsevier
Subjects
Chemical Sciences
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
KETONES
CHIRAL LIGANDS
AMINATION
KETOXIME ETHERS
REAGENTS
AMINES
KEY INTERMEDIATE
ENANTIOSELECTIVE HYDROGENATION
BORANE REDUCTION
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Summary:[Display omitted] Asymmetric hydrogenation of 2,3-dihydro-1H-inden-1-one oxime and derivatives to produce the corresponding optically active amine has been performed in the presence of rhodium and iridium catalysts. The optimization of neutral rhodium based catalytic systems by varying the operating conditions and the ligand around the metallic centre led to high conversions with moderate enantiomeric excesses.
ISSN:0957-4166
1362-511X
0957-4166
DOI:10.1016/j.tetasy.2016.02.005