Biological-clinical significance of selective loss of HLA-class-I allelic product expression in squamous-cell carcinoma of the uterine cervix

To determine possible correlations between the selective loss of HLA-class-I allelic forms on neoplastic cells and their biological-clinical characteristics, 89 squamous-cell carcinomas of the uterine cervix were evaluated immunohistochemically using monomorphic and polymorphic antibodies against HL...

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Bibliographic Details
Published inInternational journal of cancer Vol. 57; no. 5; p. 650
Main Authors Honma, S, Tsukada, S, Honda, S, Nakamura, M, Takakuwa, K, Maruhashi, T, Kodama, S, Kanazawa, K, Takahashi, T, Tanaka, K
Format Journal Article
LanguageEnglish
Published United States 01.06.1994
Subjects
Adult
Aged
Alleles
Carcinoma, Squamous Cell - immunology
Female
Histocompatibility Antigens Class I - metabolism
Humans
Immunohistochemistry
Lymphatic Metastasis
Middle Aged
Uterine Cervical Neoplasms - immunology
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Summary:To determine possible correlations between the selective loss of HLA-class-I allelic forms on neoplastic cells and their biological-clinical characteristics, 89 squamous-cell carcinomas of the uterine cervix were evaluated immunohistochemically using monomorphic and polymorphic antibodies against HLA-A, -B, and -C molecules and analyzed clinico-pathologically. Four of the carcinomas exhibited a lack of detectable class-I heavy-chain expression associated with beta 2-microglobulin. In 19 of 42 HLA-A2-positive patients, tumor cells revealed loss of the HLA-A2 allelic product. Loss of HLA-B7 and/or 40 (B7/40) allelic product(s) on tumor cells was observed in 12 of 25 HLA-B7/40-positive cases. These alterations did not correlate with patient age, clinical stage (FIGO) of the disease, histological sub-type (WHO) or depth of cervical invasion. However, a statistically significant correlation was observed between lymph-node metastases and selective loss of HLA-B7/40 allelic product(s), but not with HLA-A2 allelic product on cancer cells of the primary lesion. Our results indicate that selective loss of certain HLA-class-I alleles on neoplastic cells can influence the nodal metastatic potential and suggest that these 2 class-I molecules may have different immune functions as restriction elements in T-cell-mediated cytotoxicity.
ISSN:0020-7136
DOI:10.1002/ijc.2910570507