Effect of High Dose Acetaminophen on Liver Function Tests in Healthy Subjects

Liver function was monitored by AST, ALT, ALP and HMGB-1 (high mobility group box-1), and subjects who showed increase in LFT over twice of upper limit of normal were withdrawn from the study. The study was approved by the institutional review board of Kitasato University Hospital and performed afte...

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Published inClinical Therapeutics Vol. 39; no. 8; pp. e5 - e6
Main Authors Kumagai, Y., Song, I.D., Maeda, M., Tanaka, R., Sakamoto, Y., Aso, M., Saito, Y., Maekawa, K., Fujita, T.
Format Journal Article
LanguageEnglish
Japanese
Published Bridgewater Elsevier Inc 01.08.2017
Elsevier BV
Elsevier Limited
Subjects
Acetaminophen
Analgesics
Internal Medicine
Liver
Medical Education
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Summary:Liver function was monitored by AST, ALT, ALP and HMGB-1 (high mobility group box-1), and subjects who showed increase in LFT over twice of upper limit of normal were withdrawn from the study. The study was approved by the institutional review board of Kitasato University Hospital and performed after obtaining...
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.019