Dipicolinic acid reduces Epicoccum sorghinum symptoms on maize and inhibits tenuazonic acid biosynthesis

• Published in: Pest management science Vol. 80; no. 12; pp. 6545 - 6554
• Main Authors: Ji, Xin‐Yu, Wang, Bing‐Yi, Zhang, Yi‐Feng, Zhang, Yu‐Jing, Lai, Ya‐Jie, Yang, Yang, Wang, Xiang‐Chen, Wang, Su‐Yan, Laborda, Pedro, Shi, Xin‐Chi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2024; Wiley Subscription Services, Inc
• Subjects: Acids; Ascomycota - drug effects; Ascomycota - physiology; Bacillus metabolites; Biosynthesis; Carbendazim; carcinogenicity; Carcinogens; Conidia; Corn; Effectiveness; Epicoccum sorghinum; fungal pathogens; Fungicides; Fungicides, Industrial - pharmacology; Germination; Hyphae; In vivo methods and tests; leaf spot; Leafspot; Leaves; Lesions; maize diseases; mycelium; Mycotoxins; pathogens; Pesticides; Picolinic Acids - pharmacology; Plant Diseases - microbiology; Plant Diseases - prevention & control; Prochloraz; Tea; Tenuazonic acid; Tenuazonic Acid - pharmacology; thiram; virulent strains; Zea mays - microbiology; Bacillus metabolites; maize diseases; mycotoxins; fungal pathogens; leaf spot
• ISSN: 1526-498X; 1526-4998; 1526-4998
• DOI: 10.1002/ps.8393

BACKGROUND Epicoccum sorghinum is a pathogenic fungus that causes leaf spot in a wide range of plants, including maize, and synthesizes the mycotoxin tenuazonic acid (TEA), which is carcinogenic. Despite the relevant economic and yield losses caused by E. sorghinum worldwide, methods for the control of this pathogen are lacking. RESULTS In this work, the efficacy of Bacillus‐produced dipicolinic acid (DPA) for control of E. sorghinum was evaluated using in vitro and in vivo assays, and compared with the efficacy of three commercial fungicides, including carbendazim, prochloraz, and thiram. DPA inhibited E. sorghinum mycelial growth, and conidia germination, and produced important alterations in E. sorghinum hyphae. Interestingly, 10 mM DPA reduced TEA biosynthesis by 86.6%. Although DPA rapidly degraded on maize leaves, 10 mM DPA showed higher preventive (67.4% lesion length inhibition) and inhibitory (89.5% lesion length inhibition) efficacies for the control of E. sorghinum on maize leaves compared to the commercial fungicides. CONCLUSIONS Collectively, this study presents the first method for the control of E. sorghinum on maize and demonstrates that DPA application is a suitable approach to inhibit E. sorghinum symptoms in plants and TEA biosynthesis. © 2024 Society of Chemical Industry. Dipicolinic acid inhibited Epicoccum sorghinum mycelial growth and conidia germination, lowered tenuazonic acid accumulation, and reduced efficiently leaf spot symptoms on maize in preventive and inhibitory applications.