Allergic contact dermatitis from resacetophenone (2′,4′‐dihydroxyacetophenone; CAS no. 89‐84‐9) in an antifungal nail preparation

We report the first two cases of allergic contact dermatitis from resacetophenone in a nail antifungal preparation. Patch tests gave positive reactions to resacetophenone (0.1% and 1% pet.). No cross‐reactions with resorcinol or phenylethyl resorcinol were found. Patch testing with individual ingred...

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Bibliographic Details
Published inContact dermatitis Vol. 87; no. 6; pp. 539 - 541
Main Authors Pastor‐Nieto, María A., González‐Muñoz, Patricia, Martín‐Alcalde, Eva, Gatica‐Ortega, María E.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.12.2022
Wiley Subscription Services, Inc
Subjects
2′,4′‐dihydroxyacetophenone
4‐acetylresorcinol
Allergens
allergic contact dermatitis
antifungal
Antifungal Agents - adverse effects
CAS no. 89‐84‐9
case report
Case reports
Contact dermatitis
Contact Points
Dermatitis, Allergic Contact - diagnosis
Dermatitis, Allergic Contact - etiology
Eczema
Humans
nail
Patch Tests
phenylethyl
resacetophenone
Resorcinol
Resorcinols
phenylethyl
antifungal
resacetophenone
4-acetylresorcinol
allergic contact dermatitis
nail
CAS no. 89-84-9
case report
resorcinol
2′,4′-dihydroxyacetophenone
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Summary:We report the first two cases of allergic contact dermatitis from resacetophenone in a nail antifungal preparation. Patch tests gave positive reactions to resacetophenone (0.1% and 1% pet.). No cross‐reactions with resorcinol or phenylethyl resorcinol were found. Patch testing with individual ingredients is paramount to diagnose new allergens.
ISSN:0105-1873
1600-0536
DOI:10.1111/cod.14202