Expression of miRNA-140 in Chondrocytes and Synovial Fluid of Knee Joints in Patients with Osteoarthritis

• Published in: Chinese medical sciences journal Vol. 31; no. 4; pp. 207 - 212
• Main Authors: Si, Hai-bo, Zeng, Yi, Zhou, Zong-ke, Pei, Fu-xing, Lu, Yan-rong, Cheng, Jing-qiu, Shen, Bin
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.12.2016; Department of 0rthopedics, Regenerative Medicine Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China%Key Laboratory of Transplant Engineering and Immunology, Regenerative Medicine Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China
• Subjects: Adult; Aged; Cells, Cultured; chondrocytes; Chondrocytes - metabolism; Female; fluid; Humans; Knee Joint - metabolism; Male; microRNA-140; MicroRNAs - analysis; Middle Aged; osteoarthritis; Osteoarthritis, Knee - metabolism; Real-Time Polymerase Chain Reaction; synovial; synovial fluid; Synovial Fluid - metabolism; chondrocytes; microRNA-140; osteoarthritis; synovial fluid

Objective To investigate the expression of miRNA-140 in chondrocytes and synovial fluid ofosteoarthritis (OA) patients, and explore the relationship between the miRNA-140 expression and OAseverity.Methods This study enrolled 30 OA patients who underwent total knee arthroplasty for chondrocytessampli...