Everted rat intestinal sacs as an in vitro model for assessing absorptivity of new drugs

An in vitro model that utilizes everted rat intestinal sacs was evaluated for assessing the absorptivity of several analogs of potential drug substances prior to formulation work and clinical trials. This model not only is a useful qualitative tool for assessing absorptivity of structurally related...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 66; no. 9; p. 1249
Main Authors Chowhan, Z T, Amaro, A A
Format Journal Article
LanguageEnglish
Published United States 01.09.1977
Subjects
Animals
Chromatography, Thin Layer
Hydrogen-Ion Concentration
In Vitro Techniques
Intestinal Absorption
Intestine, Small - metabolism
Male
Models, Biological
Permeability
Pharmaceutical Preparations - metabolism
Rats
Time Factors
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Summary:An in vitro model that utilizes everted rat intestinal sacs was evaluated for assessing the absorptivity of several analogs of potential drug substances prior to formulation work and clinical trials. This model not only is a useful qualitative tool for assessing absorptivity of structurally related compounds but also yields some insight into the process involved in drug absorption. Notwithstanding the complexities involved in the absorption processes, the data support the hypothesis that the absorption of organic electrolytes mainly takes place by the partitioning of the unionized species into the lipoidal membranes and then diffusion.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600660911