Fine Mapping of Five Human Skeletal Muscle Genes: Alpha-Tropomyosin, Beta-Tropomyosin, Troponin-I Slow-Twitch, Troponin-I Fast-Twitch, and Troponin-C Fast

• Published in: Biochemical and biophysical research communications Vol. 230; no. 2; pp. 347 - 350
• Main Authors: Tiso, Natascia, Rampoldi, Luca, Pallavicini, Alberto, Zimbello, Rosanna, Pandolfo, Davide, Valle, Giorgio, Lanfranchi, Gerolamo, Danieli, Gian Antonio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.01.1997
• Subjects: Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 20; Chromosomes, Human, Pair 9; DNA Primers; Humans; Molecular Sequence Data; Multigene Family; Muscle Fibers, Fast-Twitch - metabolism; Muscle Fibers, Slow-Twitch - metabolism; Muscle, Skeletal - metabolism; Polymerase Chain Reaction; Space life sciences; Tropomyosin - biosynthesis; Tropomyosin - genetics; Troponin C - biosynthesis; Troponin C - genetics; Troponin I - biosynthesis; Troponin I - genetics
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1006/bbrc.1996.5958

In this paper the chromosomal localization of the human skeletal muscle genes Troponin-I slow-twitch (TNNI1), Troponin-I fast-twitch (TNNI2), and Troponin-C fast (TNNC2) and the refinement of the position for alpha-Tropomyosin (TPM1) and beta-Tropomyosin (TPM2) are reported. By radiation hybrid mapping, TPM1 was assigned to chromosome 15q22.1, TPM2 to chromosome 9p13.2-p13.1, TNNI1 to chromosome 1q31.3, TNNI2 to chromosome 11p15.5, and TNNC2 to chromosome 20q12-q13.11. The genomic distribution of these genes is discussed, with particular emphasis on the cluster organization of the Troponin genes.