SYNTHESIS OF CYCLOALKYL/STEROIDAL HETEROARYL SULFIDES USING RHODIUM-CATALYZED HETEROARYL EXCHANGE REACTION

Cycloalkyl heteroaryl sulfides are efficiently synthesized by the single -bond cleavage and exchange reaction of S-cycloalkyl thioesters and heteroaryl ethers without using a base. The method is applicable to steroids at the A- and D -rings, and provides diverse heteroarylthiolated steroids with fiv...

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Bibliographic Details
Published inHeterocycles Vol. 100; no. 1; pp. 104 - 118
Main Authors Arisawa, Mieko, Nakai, Katsuya, Yamada, Tomoki, Suzuki, Ren, Yamaguchi, Masahiko
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.2020
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ARYL SULFIDES
THIOLS
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Summary:Cycloalkyl heteroaryl sulfides are efficiently synthesized by the single -bond cleavage and exchange reaction of S-cycloalkyl thioesters and heteroaryl ethers without using a base. The method is applicable to steroids at the A- and D -rings, and provides diverse heteroarylthiolated steroids with five- and six -membered heteroarenes.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-19-14147