Silver(I) complexes with amino acid and dipeptide ligands – Chemical and antimicrobial relevant comparison (mini review)

• Published in: Bioorganic chemistry Vol. 141; p. 106907
• Main Authors: Vargová, Zuzana, Olejníková, Petra, Kuzderová, Gabriela, Rendošová, Michaela, Havlíčková, Jana, Gyepes, Róbert, Vilková, Mária
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2023
• ISSN: 0045-2068; 1090-2120
• DOI: 10.1016/j.bioorg.2023.106907

[Display omitted] •Mini review provides a summary of the chemical properties, and especially biological activity of selected silver(I) amino acidate and dipeptide complexes.•One set biological experiment allows their reliable comparison.•The review offers an interesting insight into the correlation between the chemical composition and potential mechanism of action of Ag(I) complexes. Diseases caused by various microorganisms accompany humans (as well as animals) throughout their whole lives. After germs penetration to the body, the incubation period and infection developing, an infection can cause mild or severe symptoms, not infrequently even death. The immune system naturally defends itself against pathogens with various mechanisms. One of them is the synthesis of antimicrobial peptides. In the case of serious and severe infections, it is currently possible to help the natural immunity by administration of antimicrobial drugs (AMB) with good success since their discovery at the beginning of the last century. However, their excessive use leads to the development of pathogenic microorganisms’ resistance to AMB drugs. Based on this, it is necessary to constantly develop new classes of AMB drugs that will be effective against pathogens, even resistant ones. The field of bioinorganic chemistry, similarly to other biological, chemical, or pharmaceutical sciences, discovers various options and approaches for antimicrobial treatment, from the development of new drugs to drug delivery systems. One of the approaches is the design and preparation of potential drugs based on metal ions and antimicrobial peptides. Various metal ions and amino acid or peptide ligands are used for this purpose. In this mini review, we focused on a reliable comparison of the chemical structure and biological properties of selected silver(I) complexes based on amino acids and dipeptides.