Genetic risk for acquired arrhythmia

Mutations and polymorphisms of the genes encoding cardiac ion channels have been reported in patients with drug-induced long QT syndrome. A recent study has demonstrated an association of a polymorphism (S1102Y) of the cardiac Na + channel gene ( SCN5A) with an increased risk of acquired arrhythmia...

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Bibliographic Details
Published inTrends in genetics Vol. 19; no. 9; pp. 470 - 473
Main Authors Behr, Elijah R., McKenna, William J.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.09.2003
Elsevier Science
Subjects
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Electrocardiography
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Genetics of eukaryotes. Biological and molecular evolution
Heart
Human
Humans
Long QT Syndrome - chemically induced
Long QT Syndrome - genetics
Long QT Syndrome - physiopathology
Medical sciences
Mutation
NAV1.5 Voltage-Gated Sodium Channel
Polymorphism, Genetic
Population genetics, reproduction patterns
Risk Factors
Sodium Channels - genetics
Human
Arrhythmia
Heart disease
Cardiovascular disease
Genetics
Risk
Mutation
Polymorphism
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Summary:Mutations and polymorphisms of the genes encoding cardiac ion channels have been reported in patients with drug-induced long QT syndrome. A recent study has demonstrated an association of a polymorphism (S1102Y) of the cardiac Na + channel gene ( SCN5A) with an increased risk of acquired arrhythmia among African Americans. However, the heterogeneity of the sample, together with the inherent problems of genetic association studies, limit the conclusions that can be made. Nevertheless, testing for ion channel polymorphisms could be used to reduce the risk of drug-induced arrhythmia and improve the risk stratification of common cardiac diseases that predispose to sudden death.
ISSN:0168-9525
DOI:10.1016/S0168-9525(03)00200-2