A new synthetic approach to phenothiazine-2-amines

Elaboration of a Buchwald–Hartwig protocol for the introduction of amino functions to position 2 of the phenothiazine ring system has opened a new access to various N-alkyl and N-dienyl phenothiazines bearing secondary amines, tertiary amines, and amide moieties. Hydrolysis of the amido derivatives...

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Published inTetrahedron letters Vol. 53; no. 42; pp. 5585 - 5588
Main Authors Takács, Daniella, Egyed, Orsolya, Drahos, László, Riedl, Zsuzsanna, Hajós, György
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.10.2012
Elsevier
Subjects
Amides
Amination
Amines
Bearing
Buchwald–Hartwig cross-coupling
Chemistry
Chemistry, Organic
Derivatives
Functionalization
Hydrolysis
Phenothiazine
Phenothiazines
Physical Sciences
Science & Technology
Tetrahedrons
Buchwald–Hartwig cross-coupling
Amination
Functionalization
Phenothiazine
10H-PHENOTHIAZINES
RIBOFURANOSIDES
Buchwald-Hartwig cross-coupling
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Summary:Elaboration of a Buchwald–Hartwig protocol for the introduction of amino functions to position 2 of the phenothiazine ring system has opened a new access to various N-alkyl and N-dienyl phenothiazines bearing secondary amines, tertiary amines, and amide moieties. Hydrolysis of the amido derivatives gave unsubstituted phenothiazine-2-amines. This protocol provides an easy access to phenothiazine-2-amines starting from the commercially available starting compounds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.07.083