Chlorpromazine disposition in relation to age in children

The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children. The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (...

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Bibliographic Details
Published inClinical pharmacokinetics Vol. 18; no. 4; p. 329
Main Authors Furlanut, M, Benetello, P, Baraldo, M, Zara, G, Montanari, G, Donzelli, F
Format Journal Article
LanguageEnglish
Published Switzerland 01.04.1990
Subjects
Adolescent
Age Factors
Child
Child, Preschool
Chlorpromazine - administration & dosage
Chlorpromazine - pharmacokinetics
Female
Humans
Infant
Infusions, Intravenous
Male
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Summary:The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children. The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (r = -0.43). It appears that the pharmacokinetics of chlorpromazine are more rapid in children than in adults.
ISSN:0312-5963
DOI:10.2165/00003088-199018040-00005